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(A) Schematic representing Functional <t>ultrasound</t> (fUS) imaging and whisker stimulation set-up along with the coronal slice of interest encompassing somatosensory cortex, Barrel field (grey-dotted oval) (left). Activation map generated with Pearson’s correlation coefficient in response to left-side whisker stimulation, with grey-dotted oval denoting contralateral activation, for control (middle) and 5xFAD (right) shown. (B) Time course of normalized rCBV change in control (black) and 5xFAD (red), the duration of recording is 240s with two 30s stimulation period (grey shaded area). (C) Comparison of steady-state change in rCBV at first whisker stimulus period (WS 1 ) between control and 5xFAD. The 5xFAD mice show reduction in steady-state rCBV change at 3-month-old. (Control: 16 ± 0.55 vs. 5xFAD: 11 ± 1.2 %, **p<0.01, unpaired t-test, n=8). (D) Representative trace of control (top) and 5xFAD (bottom) showing WS 1 period, note the three phases, fast rise kinetics (P fast , light blue), slow rise kinetics (P slow , purple), and decay kinetics (P decay , green). (E) Comparison of the time constant (τ) for control and 5xFAD from exponential fit of the slow (Control: 3.1 ± 0.98 vs. 5xFAD: 2.3 ± 0.56 sec, ns, unpaired t-test, n=8) and decay kinetics (Control: 1.6 ± 0.42 vs. 5xFAD: 2.1 ± 0.45 sec, ns, unpaired t-test, n=8), respectively. (F) Comparison of the fast phase duration between control and 5xFAD mice (Control: 2.4 ± 0.32 vs 5xFAD: 3.9 ± 0.46 sec, * p<0.05, n=8). (G and H) Comparison of two transition impairment parameters: (G) amplitude drop (A drop, Control: −2.2 ± 0.51 vs. 5xFAD: −7.4 ± 1.6 %, ** p<0.01, unpaired t-test, n=8) and (H) difference in transition time between fast and slow phase (ΔT drop , Control: 0.29 ± 0.14 vs. 5xFAD:1.2 ± 0.31 sec, *p<0.05, unpaired t-test, n=8). (I) Representative CBF maps for control (top) and 5xFAD (bottom) overlaid on top of anatomical images obtained from MRI. (J) Comparison of average CBF of cortex (top; neocortex; control: 135 ± 19 vs. 5xFAD: 152 ± 15 ml/100g/min, ns; SSC-BF; control: 145 ± 19 vs. 5xFAD: 166 ± 17 ml/100g/min, ns, unpaired t-test, n=7-13) and deep brain regions (bottom; hippocampus; control: 107 ± 17 vs. 5xFAD: 133 ± 20 ml/100g/min, ns; thalamus; control: 71 ± 13 vs. 5xFAD: 86 ± 14 ml/100g/min, ns; hypothalamus; control: 65 ± 10 vs. 5xFAD: 74 ± 9.1 ml/100g/min, ns, unpaired t-test, n=7-13). (K) Representative anatomical image of control (top) and 5xFAD (bottom) coronal section with blue shaded area indicating the mask of area used for cortical thickness measurements. (L) Comparison of cortical thickness between control and 5xFAD (control: 0.94 ± 0.018 vs. 5xFAD: 0.89 ± 0.021 mm, ns, unpaired t-test, n=7-13).
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(A) Schematic representing Functional <t>ultrasound</t> (fUS) imaging and whisker stimulation set-up along with the coronal slice of interest encompassing somatosensory cortex, Barrel field (grey-dotted oval) (left). Activation map generated with Pearson’s correlation coefficient in response to left-side whisker stimulation, with grey-dotted oval denoting contralateral activation, for control (middle) and 5xFAD (right) shown. (B) Time course of normalized rCBV change in control (black) and 5xFAD (red), the duration of recording is 240s with two 30s stimulation period (grey shaded area). (C) Comparison of steady-state change in rCBV at first whisker stimulus period (WS 1 ) between control and 5xFAD. The 5xFAD mice show reduction in steady-state rCBV change at 3-month-old. (Control: 16 ± 0.55 vs. 5xFAD: 11 ± 1.2 %, **p<0.01, unpaired t-test, n=8). (D) Representative trace of control (top) and 5xFAD (bottom) showing WS 1 period, note the three phases, fast rise kinetics (P fast , light blue), slow rise kinetics (P slow , purple), and decay kinetics (P decay , green). (E) Comparison of the time constant (τ) for control and 5xFAD from exponential fit of the slow (Control: 3.1 ± 0.98 vs. 5xFAD: 2.3 ± 0.56 sec, ns, unpaired t-test, n=8) and decay kinetics (Control: 1.6 ± 0.42 vs. 5xFAD: 2.1 ± 0.45 sec, ns, unpaired t-test, n=8), respectively. (F) Comparison of the fast phase duration between control and 5xFAD mice (Control: 2.4 ± 0.32 vs 5xFAD: 3.9 ± 0.46 sec, * p<0.05, n=8). (G and H) Comparison of two transition impairment parameters: (G) amplitude drop (A drop, Control: −2.2 ± 0.51 vs. 5xFAD: −7.4 ± 1.6 %, ** p<0.01, unpaired t-test, n=8) and (H) difference in transition time between fast and slow phase (ΔT drop , Control: 0.29 ± 0.14 vs. 5xFAD:1.2 ± 0.31 sec, *p<0.05, unpaired t-test, n=8). (I) Representative CBF maps for control (top) and 5xFAD (bottom) overlaid on top of anatomical images obtained from MRI. (J) Comparison of average CBF of cortex (top; neocortex; control: 135 ± 19 vs. 5xFAD: 152 ± 15 ml/100g/min, ns; SSC-BF; control: 145 ± 19 vs. 5xFAD: 166 ± 17 ml/100g/min, ns, unpaired t-test, n=7-13) and deep brain regions (bottom; hippocampus; control: 107 ± 17 vs. 5xFAD: 133 ± 20 ml/100g/min, ns; thalamus; control: 71 ± 13 vs. 5xFAD: 86 ± 14 ml/100g/min, ns; hypothalamus; control: 65 ± 10 vs. 5xFAD: 74 ± 9.1 ml/100g/min, ns, unpaired t-test, n=7-13). (K) Representative anatomical image of control (top) and 5xFAD (bottom) coronal section with blue shaded area indicating the mask of area used for cortical thickness measurements. (L) Comparison of cortical thickness between control and 5xFAD (control: 0.94 ± 0.018 vs. 5xFAD: 0.89 ± 0.021 mm, ns, unpaired t-test, n=7-13).
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(A) Schematic representing Functional <t>ultrasound</t> (fUS) imaging and whisker stimulation set-up along with the coronal slice of interest encompassing somatosensory cortex, Barrel field (grey-dotted oval) (left). Activation map generated with Pearson’s correlation coefficient in response to left-side whisker stimulation, with grey-dotted oval denoting contralateral activation, for control (middle) and 5xFAD (right) shown. (B) Time course of normalized rCBV change in control (black) and 5xFAD (red), the duration of recording is 240s with two 30s stimulation period (grey shaded area). (C) Comparison of steady-state change in rCBV at first whisker stimulus period (WS 1 ) between control and 5xFAD. The 5xFAD mice show reduction in steady-state rCBV change at 3-month-old. (Control: 16 ± 0.55 vs. 5xFAD: 11 ± 1.2 %, **p<0.01, unpaired t-test, n=8). (D) Representative trace of control (top) and 5xFAD (bottom) showing WS 1 period, note the three phases, fast rise kinetics (P fast , light blue), slow rise kinetics (P slow , purple), and decay kinetics (P decay , green). (E) Comparison of the time constant (τ) for control and 5xFAD from exponential fit of the slow (Control: 3.1 ± 0.98 vs. 5xFAD: 2.3 ± 0.56 sec, ns, unpaired t-test, n=8) and decay kinetics (Control: 1.6 ± 0.42 vs. 5xFAD: 2.1 ± 0.45 sec, ns, unpaired t-test, n=8), respectively. (F) Comparison of the fast phase duration between control and 5xFAD mice (Control: 2.4 ± 0.32 vs 5xFAD: 3.9 ± 0.46 sec, * p<0.05, n=8). (G and H) Comparison of two transition impairment parameters: (G) amplitude drop (A drop, Control: −2.2 ± 0.51 vs. 5xFAD: −7.4 ± 1.6 %, ** p<0.01, unpaired t-test, n=8) and (H) difference in transition time between fast and slow phase (ΔT drop , Control: 0.29 ± 0.14 vs. 5xFAD:1.2 ± 0.31 sec, *p<0.05, unpaired t-test, n=8). (I) Representative CBF maps for control (top) and 5xFAD (bottom) overlaid on top of anatomical images obtained from MRI. (J) Comparison of average CBF of cortex (top; neocortex; control: 135 ± 19 vs. 5xFAD: 152 ± 15 ml/100g/min, ns; SSC-BF; control: 145 ± 19 vs. 5xFAD: 166 ± 17 ml/100g/min, ns, unpaired t-test, n=7-13) and deep brain regions (bottom; hippocampus; control: 107 ± 17 vs. 5xFAD: 133 ± 20 ml/100g/min, ns; thalamus; control: 71 ± 13 vs. 5xFAD: 86 ± 14 ml/100g/min, ns; hypothalamus; control: 65 ± 10 vs. 5xFAD: 74 ± 9.1 ml/100g/min, ns, unpaired t-test, n=7-13). (K) Representative anatomical image of control (top) and 5xFAD (bottom) coronal section with blue shaded area indicating the mask of area used for cortical thickness measurements. (L) Comparison of cortical thickness between control and 5xFAD (control: 0.94 ± 0.018 vs. 5xFAD: 0.89 ± 0.021 mm, ns, unpaired t-test, n=7-13).
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(A) Schematic representing Functional <t>ultrasound</t> (fUS) imaging and whisker stimulation set-up along with the coronal slice of interest encompassing somatosensory cortex, Barrel field (grey-dotted oval) (left). Activation map generated with Pearson’s correlation coefficient in response to left-side whisker stimulation, with grey-dotted oval denoting contralateral activation, for control (middle) and 5xFAD (right) shown. (B) Time course of normalized rCBV change in control (black) and 5xFAD (red), the duration of recording is 240s with two 30s stimulation period (grey shaded area). (C) Comparison of steady-state change in rCBV at first whisker stimulus period (WS 1 ) between control and 5xFAD. The 5xFAD mice show reduction in steady-state rCBV change at 3-month-old. (Control: 16 ± 0.55 vs. 5xFAD: 11 ± 1.2 %, **p<0.01, unpaired t-test, n=8). (D) Representative trace of control (top) and 5xFAD (bottom) showing WS 1 period, note the three phases, fast rise kinetics (P fast , light blue), slow rise kinetics (P slow , purple), and decay kinetics (P decay , green). (E) Comparison of the time constant (τ) for control and 5xFAD from exponential fit of the slow (Control: 3.1 ± 0.98 vs. 5xFAD: 2.3 ± 0.56 sec, ns, unpaired t-test, n=8) and decay kinetics (Control: 1.6 ± 0.42 vs. 5xFAD: 2.1 ± 0.45 sec, ns, unpaired t-test, n=8), respectively. (F) Comparison of the fast phase duration between control and 5xFAD mice (Control: 2.4 ± 0.32 vs 5xFAD: 3.9 ± 0.46 sec, * p<0.05, n=8). (G and H) Comparison of two transition impairment parameters: (G) amplitude drop (A drop, Control: −2.2 ± 0.51 vs. 5xFAD: −7.4 ± 1.6 %, ** p<0.01, unpaired t-test, n=8) and (H) difference in transition time between fast and slow phase (ΔT drop , Control: 0.29 ± 0.14 vs. 5xFAD:1.2 ± 0.31 sec, *p<0.05, unpaired t-test, n=8). (I) Representative CBF maps for control (top) and 5xFAD (bottom) overlaid on top of anatomical images obtained from MRI. (J) Comparison of average CBF of cortex (top; neocortex; control: 135 ± 19 vs. 5xFAD: 152 ± 15 ml/100g/min, ns; SSC-BF; control: 145 ± 19 vs. 5xFAD: 166 ± 17 ml/100g/min, ns, unpaired t-test, n=7-13) and deep brain regions (bottom; hippocampus; control: 107 ± 17 vs. 5xFAD: 133 ± 20 ml/100g/min, ns; thalamus; control: 71 ± 13 vs. 5xFAD: 86 ± 14 ml/100g/min, ns; hypothalamus; control: 65 ± 10 vs. 5xFAD: 74 ± 9.1 ml/100g/min, ns, unpaired t-test, n=7-13). (K) Representative anatomical image of control (top) and 5xFAD (bottom) coronal section with blue shaded area indicating the mask of area used for cortical thickness measurements. (L) Comparison of cortical thickness between control and 5xFAD (control: 0.94 ± 0.018 vs. 5xFAD: 0.89 ± 0.021 mm, ns, unpaired t-test, n=7-13).
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(A) Schematic representing Functional <t>ultrasound</t> (fUS) imaging and whisker stimulation set-up along with the coronal slice of interest encompassing somatosensory cortex, Barrel field (grey-dotted oval) (left). Activation map generated with Pearson’s correlation coefficient in response to left-side whisker stimulation, with grey-dotted oval denoting contralateral activation, for control (middle) and 5xFAD (right) shown. (B) Time course of normalized rCBV change in control (black) and 5xFAD (red), the duration of recording is 240s with two 30s stimulation period (grey shaded area). (C) Comparison of steady-state change in rCBV at first whisker stimulus period (WS 1 ) between control and 5xFAD. The 5xFAD mice show reduction in steady-state rCBV change at 3-month-old. (Control: 16 ± 0.55 vs. 5xFAD: 11 ± 1.2 %, **p<0.01, unpaired t-test, n=8). (D) Representative trace of control (top) and 5xFAD (bottom) showing WS 1 period, note the three phases, fast rise kinetics (P fast , light blue), slow rise kinetics (P slow , purple), and decay kinetics (P decay , green). (E) Comparison of the time constant (τ) for control and 5xFAD from exponential fit of the slow (Control: 3.1 ± 0.98 vs. 5xFAD: 2.3 ± 0.56 sec, ns, unpaired t-test, n=8) and decay kinetics (Control: 1.6 ± 0.42 vs. 5xFAD: 2.1 ± 0.45 sec, ns, unpaired t-test, n=8), respectively. (F) Comparison of the fast phase duration between control and 5xFAD mice (Control: 2.4 ± 0.32 vs 5xFAD: 3.9 ± 0.46 sec, * p<0.05, n=8). (G and H) Comparison of two transition impairment parameters: (G) amplitude drop (A drop, Control: −2.2 ± 0.51 vs. 5xFAD: −7.4 ± 1.6 %, ** p<0.01, unpaired t-test, n=8) and (H) difference in transition time between fast and slow phase (ΔT drop , Control: 0.29 ± 0.14 vs. 5xFAD:1.2 ± 0.31 sec, *p<0.05, unpaired t-test, n=8). (I) Representative CBF maps for control (top) and 5xFAD (bottom) overlaid on top of anatomical images obtained from MRI. (J) Comparison of average CBF of cortex (top; neocortex; control: 135 ± 19 vs. 5xFAD: 152 ± 15 ml/100g/min, ns; SSC-BF; control: 145 ± 19 vs. 5xFAD: 166 ± 17 ml/100g/min, ns, unpaired t-test, n=7-13) and deep brain regions (bottom; hippocampus; control: 107 ± 17 vs. 5xFAD: 133 ± 20 ml/100g/min, ns; thalamus; control: 71 ± 13 vs. 5xFAD: 86 ± 14 ml/100g/min, ns; hypothalamus; control: 65 ± 10 vs. 5xFAD: 74 ± 9.1 ml/100g/min, ns, unpaired t-test, n=7-13). (K) Representative anatomical image of control (top) and 5xFAD (bottom) coronal section with blue shaded area indicating the mask of area used for cortical thickness measurements. (L) Comparison of cortical thickness between control and 5xFAD (control: 0.94 ± 0.018 vs. 5xFAD: 0.89 ± 0.021 mm, ns, unpaired t-test, n=7-13).
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(A) Schematic representing Functional <t>ultrasound</t> (fUS) imaging and whisker stimulation set-up along with the coronal slice of interest encompassing somatosensory cortex, Barrel field (grey-dotted oval) (left). Activation map generated with Pearson’s correlation coefficient in response to left-side whisker stimulation, with grey-dotted oval denoting contralateral activation, for control (middle) and 5xFAD (right) shown. (B) Time course of normalized rCBV change in control (black) and 5xFAD (red), the duration of recording is 240s with two 30s stimulation period (grey shaded area). (C) Comparison of steady-state change in rCBV at first whisker stimulus period (WS 1 ) between control and 5xFAD. The 5xFAD mice show reduction in steady-state rCBV change at 3-month-old. (Control: 16 ± 0.55 vs. 5xFAD: 11 ± 1.2 %, **p<0.01, unpaired t-test, n=8). (D) Representative trace of control (top) and 5xFAD (bottom) showing WS 1 period, note the three phases, fast rise kinetics (P fast , light blue), slow rise kinetics (P slow , purple), and decay kinetics (P decay , green). (E) Comparison of the time constant (τ) for control and 5xFAD from exponential fit of the slow (Control: 3.1 ± 0.98 vs. 5xFAD: 2.3 ± 0.56 sec, ns, unpaired t-test, n=8) and decay kinetics (Control: 1.6 ± 0.42 vs. 5xFAD: 2.1 ± 0.45 sec, ns, unpaired t-test, n=8), respectively. (F) Comparison of the fast phase duration between control and 5xFAD mice (Control: 2.4 ± 0.32 vs 5xFAD: 3.9 ± 0.46 sec, * p<0.05, n=8). (G and H) Comparison of two transition impairment parameters: (G) amplitude drop (A drop, Control: −2.2 ± 0.51 vs. 5xFAD: −7.4 ± 1.6 %, ** p<0.01, unpaired t-test, n=8) and (H) difference in transition time between fast and slow phase (ΔT drop , Control: 0.29 ± 0.14 vs. 5xFAD:1.2 ± 0.31 sec, *p<0.05, unpaired t-test, n=8). (I) Representative CBF maps for control (top) and 5xFAD (bottom) overlaid on top of anatomical images obtained from MRI. (J) Comparison of average CBF of cortex (top; neocortex; control: 135 ± 19 vs. 5xFAD: 152 ± 15 ml/100g/min, ns; SSC-BF; control: 145 ± 19 vs. 5xFAD: 166 ± 17 ml/100g/min, ns, unpaired t-test, n=7-13) and deep brain regions (bottom; hippocampus; control: 107 ± 17 vs. 5xFAD: 133 ± 20 ml/100g/min, ns; thalamus; control: 71 ± 13 vs. 5xFAD: 86 ± 14 ml/100g/min, ns; hypothalamus; control: 65 ± 10 vs. 5xFAD: 74 ± 9.1 ml/100g/min, ns, unpaired t-test, n=7-13). (K) Representative anatomical image of control (top) and 5xFAD (bottom) coronal section with blue shaded area indicating the mask of area used for cortical thickness measurements. (L) Comparison of cortical thickness between control and 5xFAD (control: 0.94 ± 0.018 vs. 5xFAD: 0.89 ± 0.021 mm, ns, unpaired t-test, n=7-13).
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Image Search Results


(A) Schematic representing Functional ultrasound (fUS) imaging and whisker stimulation set-up along with the coronal slice of interest encompassing somatosensory cortex, Barrel field (grey-dotted oval) (left). Activation map generated with Pearson’s correlation coefficient in response to left-side whisker stimulation, with grey-dotted oval denoting contralateral activation, for control (middle) and 5xFAD (right) shown. (B) Time course of normalized rCBV change in control (black) and 5xFAD (red), the duration of recording is 240s with two 30s stimulation period (grey shaded area). (C) Comparison of steady-state change in rCBV at first whisker stimulus period (WS 1 ) between control and 5xFAD. The 5xFAD mice show reduction in steady-state rCBV change at 3-month-old. (Control: 16 ± 0.55 vs. 5xFAD: 11 ± 1.2 %, **p<0.01, unpaired t-test, n=8). (D) Representative trace of control (top) and 5xFAD (bottom) showing WS 1 period, note the three phases, fast rise kinetics (P fast , light blue), slow rise kinetics (P slow , purple), and decay kinetics (P decay , green). (E) Comparison of the time constant (τ) for control and 5xFAD from exponential fit of the slow (Control: 3.1 ± 0.98 vs. 5xFAD: 2.3 ± 0.56 sec, ns, unpaired t-test, n=8) and decay kinetics (Control: 1.6 ± 0.42 vs. 5xFAD: 2.1 ± 0.45 sec, ns, unpaired t-test, n=8), respectively. (F) Comparison of the fast phase duration between control and 5xFAD mice (Control: 2.4 ± 0.32 vs 5xFAD: 3.9 ± 0.46 sec, * p<0.05, n=8). (G and H) Comparison of two transition impairment parameters: (G) amplitude drop (A drop, Control: −2.2 ± 0.51 vs. 5xFAD: −7.4 ± 1.6 %, ** p<0.01, unpaired t-test, n=8) and (H) difference in transition time between fast and slow phase (ΔT drop , Control: 0.29 ± 0.14 vs. 5xFAD:1.2 ± 0.31 sec, *p<0.05, unpaired t-test, n=8). (I) Representative CBF maps for control (top) and 5xFAD (bottom) overlaid on top of anatomical images obtained from MRI. (J) Comparison of average CBF of cortex (top; neocortex; control: 135 ± 19 vs. 5xFAD: 152 ± 15 ml/100g/min, ns; SSC-BF; control: 145 ± 19 vs. 5xFAD: 166 ± 17 ml/100g/min, ns, unpaired t-test, n=7-13) and deep brain regions (bottom; hippocampus; control: 107 ± 17 vs. 5xFAD: 133 ± 20 ml/100g/min, ns; thalamus; control: 71 ± 13 vs. 5xFAD: 86 ± 14 ml/100g/min, ns; hypothalamus; control: 65 ± 10 vs. 5xFAD: 74 ± 9.1 ml/100g/min, ns, unpaired t-test, n=7-13). (K) Representative anatomical image of control (top) and 5xFAD (bottom) coronal section with blue shaded area indicating the mask of area used for cortical thickness measurements. (L) Comparison of cortical thickness between control and 5xFAD (control: 0.94 ± 0.018 vs. 5xFAD: 0.89 ± 0.021 mm, ns, unpaired t-test, n=7-13).

Journal: bioRxiv

Article Title: Electro-Calcium uncoupling precedes neurodegeneration in Alzheimer’s disease

doi: 10.64898/2026.01.26.701803

Figure Lengend Snippet: (A) Schematic representing Functional ultrasound (fUS) imaging and whisker stimulation set-up along with the coronal slice of interest encompassing somatosensory cortex, Barrel field (grey-dotted oval) (left). Activation map generated with Pearson’s correlation coefficient in response to left-side whisker stimulation, with grey-dotted oval denoting contralateral activation, for control (middle) and 5xFAD (right) shown. (B) Time course of normalized rCBV change in control (black) and 5xFAD (red), the duration of recording is 240s with two 30s stimulation period (grey shaded area). (C) Comparison of steady-state change in rCBV at first whisker stimulus period (WS 1 ) between control and 5xFAD. The 5xFAD mice show reduction in steady-state rCBV change at 3-month-old. (Control: 16 ± 0.55 vs. 5xFAD: 11 ± 1.2 %, **p<0.01, unpaired t-test, n=8). (D) Representative trace of control (top) and 5xFAD (bottom) showing WS 1 period, note the three phases, fast rise kinetics (P fast , light blue), slow rise kinetics (P slow , purple), and decay kinetics (P decay , green). (E) Comparison of the time constant (τ) for control and 5xFAD from exponential fit of the slow (Control: 3.1 ± 0.98 vs. 5xFAD: 2.3 ± 0.56 sec, ns, unpaired t-test, n=8) and decay kinetics (Control: 1.6 ± 0.42 vs. 5xFAD: 2.1 ± 0.45 sec, ns, unpaired t-test, n=8), respectively. (F) Comparison of the fast phase duration between control and 5xFAD mice (Control: 2.4 ± 0.32 vs 5xFAD: 3.9 ± 0.46 sec, * p<0.05, n=8). (G and H) Comparison of two transition impairment parameters: (G) amplitude drop (A drop, Control: −2.2 ± 0.51 vs. 5xFAD: −7.4 ± 1.6 %, ** p<0.01, unpaired t-test, n=8) and (H) difference in transition time between fast and slow phase (ΔT drop , Control: 0.29 ± 0.14 vs. 5xFAD:1.2 ± 0.31 sec, *p<0.05, unpaired t-test, n=8). (I) Representative CBF maps for control (top) and 5xFAD (bottom) overlaid on top of anatomical images obtained from MRI. (J) Comparison of average CBF of cortex (top; neocortex; control: 135 ± 19 vs. 5xFAD: 152 ± 15 ml/100g/min, ns; SSC-BF; control: 145 ± 19 vs. 5xFAD: 166 ± 17 ml/100g/min, ns, unpaired t-test, n=7-13) and deep brain regions (bottom; hippocampus; control: 107 ± 17 vs. 5xFAD: 133 ± 20 ml/100g/min, ns; thalamus; control: 71 ± 13 vs. 5xFAD: 86 ± 14 ml/100g/min, ns; hypothalamus; control: 65 ± 10 vs. 5xFAD: 74 ± 9.1 ml/100g/min, ns, unpaired t-test, n=7-13). (K) Representative anatomical image of control (top) and 5xFAD (bottom) coronal section with blue shaded area indicating the mask of area used for cortical thickness measurements. (L) Comparison of cortical thickness between control and 5xFAD (control: 0.94 ± 0.018 vs. 5xFAD: 0.89 ± 0.021 mm, ns, unpaired t-test, n=7-13).

Article Snippet: Iconeus One system (Iconeus, Paris, France) equipped with linear ultrasound probe (IcoPrime-15MHz, Iconeus) mounted on a linear motorized stage was used for fUS.

Techniques: Functional Assay, Imaging, Whisker Assay, Activation Assay, Generated, Control, Comparison